Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 3rd World Congress on Human Genetics and Genetic Disorders Toronto,Canada.

Day 2 :

Keynote Forum

Manjeet S Mehta

GENETIC WORLD, Molecular Genetics Laboratory, India

Keynote: Putting together the pieces of the genome puzzle

Time : 09:45-10:45

OMICS International Human Genetics Congress 2017 International Conference Keynote Speaker Manjeet S Mehta  photo
Biography:

Manjeet S Mehta is renowned Medical Geneticist from India par excellence. She has a rich experience of more than 3 decades in Human Genetics. She has worked with top hospitals in Bombay including Kokilaben Hospital, Jaslok Hospital, Lilavati Hospital, etc. She has set up the Genetic Department at the country’s leading chain of referral labs. She has worked with Indian Council for Medical Research (ICMR), India’s pioneer institute for biomedical research. After completing PhD, she has also gained advanced training at North York General Hospital, Toronto, and St. George’s Hospital, London. She is in the Review Board for several journals. She is an invited speaker at several conferences worldwide including the World Congress of Perinatal Medicine to be held in Belgrade this year.

Abstract:

Genetics is the basic science for biology and medicine. This truth is getting wider acceptance by the medical community as nowadays any disease of any system, monogenic to multifactorial and infectious disease to cancers, needs a molecular diagnosis. There is extensive use of cytogenetic and molecular genetic techniques in cancer diagnostics, prognostication and treatment. The importance of genetic testing is accepted by clinicians as has been well proved. There is a great need of better understanding of the genetic aspects of birth defects and principles of genetic techniques so that genetic testing can be appropriately used for the benefit of evaluation of fetal anomalies and providing genetic counseling and prenatal diagnosis to the families. Genomic techniques which can analyze the whole genome in one go have made genetic testing easier and the techniques of microarray and exome/genome sequencing are being applied in clinical situations more and more frequently. It has become practically the first-tier test for most of the genetic disorders by exome sequencing for neurogenetic disorders. The cost of this latest technological marvel is within the reach of many families and the costs are likely to come down further. There are some interesting issues about next generation sequencing in medicine. Also, there is importance of knowing the significance of each nucleotide in the genome, so that the exome sequencing data can be analyzed in a more meaningful manner and with more confidence. As more and more exomes are sequenced, more and more data about pathogenic and polymorphic sequence variations is getting accumulated and these comprehensive databases will ease the challenging task of genome/exome analysis to some extent. The whole objective of diagnosis is finding a path towards curative treatment. So, at this juncture, when the clinicians are gradually getting prepared for molecular medicine, the scientific community is putting together some more pieces of the extremely complex puzzle of human physiology and pathology using genomic techniques. Medicine will take some big leaps in the next decade or two.
 

Keynote Forum

Rezvan Mirzaee

Iran University of Medical Sciences, Iran

Keynote: Study of VCAM-1 expression in normal and tumoral tissues in patients with colorectal cancer

Time : 11:05-12:05

OMICS International Human Genetics Congress 2017 International Conference Keynote Speaker Rezvan Mirzaee  photo
Biography:

Rezvan Mirzaee is an Associate Professor of Colorectal Surgery. She has completed her Graduation from Iran University of Medical Sciences. She is a Member of colorectal research center. She has 20 publications. She is specialized in cancer and pelvic floor disorders.

Abstract:

Aim: Colorectal cancer is one of the most commonly diagnosed cancers in the world. Cell adhesion molecules play an important role in the progression of various cancers. It has been shown that the high level expression of some Cell adhesion molecule could be a new diagnostic factor for several cancers. Vascular cell adhesion molecule-1(VCAM-1) is a cell surface glycoprotein that is expressed in the endothelium activated by cytokine. Generally VCAM-1 expression level is very poor in normal adult tissue endothelial cells. According to the above explanation, this study was conducted to investigate the VCAM-1 expression in tumoral tissues and adjacent normal tissues in colorectal cancer patients to its relation with clinicopathological features patients. Methods: In this study, 60 tumoral tissues and 39 adjacent normal tumor tissues was an evaluated by using Reverse transcriptionpolymerase chain reaction (RT-PCR) technique, as well as software SPSS and chi-square test for association of this gene with clinicopathologic features patients were used and P>0.005 was considered significant. Results: VCAM-1 gene in tumor samples (100%) and 33% of the adjacent normal samples was expressed. A significant correlation was found between VCAM-1 expression level and the stage, lymph nodes involvement, tumor progression factor of cancer and sex. VCAM-1 expression not observed in tumor samples with stage 0. No association was seen between VCAM1 expression and other clinical features such as age (P<0.103), size of the tumor (P<0.419). As well as statistically significant association between VCAM-1 expression with metastasis was not observed in these patients (P>0.276). Conclusion: According to data obtained and VCAM-1 expression relationship with tumor progression factor, lymph node involvement and the stage of the cancer, VCAM-1 expression can be in angiogenesis and proliferation of cancer cells in patients with CRC play important role, probably be considered as a prognostic biomarker for colorectal cancer.