Ellie Wright
EGW Research Institute LLC, USA
Title: Bacterial genetics: Could gut microbiota become a diagnostic biomarkers or therapeutic treatment for neurodegenerative disease
Biography
Biography: Ellie Wright
Abstract
Recent studies suggest that the gut microbiota modulates brain health and neuroinflammation. More and more evidence points to gut microbiota as a very important determining factor for prevention of neurodegenerative diseases. This research aims to look at the latest findings in the gut microbiota and their role in neurodegenerative disease like ALS, Parkinson's disease, Alzheimer's disease and Multiple Sclerosis. In a bidirectional system of gut-brain when the composition of gut microbiota is altered and leads to an increase intestinal permeability allowing bacterial peptidoglycan to translocate to the brain. Some gut microbiota implicated in the reactions of peptides or short chain fatty acids could affect gene expression and inflammation within the central nervous system. Some studies suggest that GI tract microbiota secrete pro-inflammatory neurotoxins including surface lipopolysaccharides (LPSs) playing a role in the brain health. The complex communication gut-brain involves the neural and humoral pathways with three cytokines implicated in signaling pathways TNFα, IL-1β, and IL-6. The gut-microbiota-to-brain routes have received increasing attention for their ability to modulate brain function and this research aims to review the possible underlying mechanisms of neuroinflammation and neurodegeneration related to the gut microbiota.