L. Corzo
EuroEspes Biomedical Research Center, Spain
Title: Vascular Risk Polymorphisms and Serum Atherogenic Biomarkers
Biography
Biography: L. Corzo
Abstract
The increasing involvement of vascular risk in different pathologies has generated a great interest for the development of predictive vascular markers. We evaluated different serum parameters in 192 persons presenting vascular signs: total cholesterol (TC), HDL-cholesterol (HDL), LDL-cholesterol (LDL), triglycerides (TG), apoA1, apoB, apoE, folate, vitamin B12 (B12), homocysteine, fibrinogen (FB), lipoprotein (a) (LP), and ultrasensitive-PCR (PCR). Vascular-associated genes included: APOC3, APOB, APOE, CETP, LPL, NOS3, ACE, AGT, IL1B, IL6, IL6R, TNFA, F2, F5, and MTHFR. Higher LDL levels were found in patients homozygous for APOE-4. Higher TG concentrations and apoB/apoA1 index were observed in patients with the APOB T7673T genotype. Subjects presenting CETP GG had lower levels of HDL and apoA1. The ACE D/D genotype was associated with lower levels of TC and TC/HDL index. The AGT T235T genotype was associated with decreased FB and PCR levels. IL6R A1510C polymorphism correlated with higher concentrations of B12. F5 G1691A polymorphism was found in patients with higher levels of HDL, apoA1, TC and LP. Lipid dysfunction-related genotypes (APOE allele4, APOB T7673T, CETP GG) were associated with increased atherogenic and decreased atheroprotective lipid levels. However, ACE D/D, AGT T235T and IL6R A1510C genotypes, involved in endothelial impairment, hypertension and immune response, respectively, were not associated with an atherogenic effect.