Zeynep Cengiz
Fatih University, TURKEY
Title: Epigenetics changes determination under the chronıc ethanol exposure and its withdrawal at SH-SY5Y cells
Biography
Biography: Zeynep Cengiz
Abstract
Alcoholism is a complex debilitating disease that influenced by genetic, epigenetic, and environmental factors. It has an active role on some of the gene expressions that is able to cause different types of molecular mechanism changes. Unfortunately, the genetic determinants of risk remain largely unknown, hindering effective prevention and treatment of dependent individuals. To bright up the those gene expressions that how they get effect on complex structure, we should know about gene interactions and also the epigenetic changes. The epigenetic factor is that it involves the changing of the gene activations on DNA without any methylation, phosphorylation, and any acetylation. So by this we able to observe whether if there is any gene expression that causes enzyme translocation or not.In this study, going to do research by differentitation of SH-SY5Y neuroblastoma cells and turn them through neuron like cells so, will be able to study if SH-SY5Y has any effect by chronic ethanol exposure. So showing of alcohol damages in vitro conditions and determining epigenetic changes factors we would be able to find out new gen markers for future treatments and develop new threapeutic agents. We would also be able to figure out how transplanted tissue can be treated by SH-SY5Y cell lines in the project so we can mimic it to real transplant tissue sample when it has alcohol consumption condition.