Human Genetics

Biography

Biography: Vladislav S BaranovFabrício R. Santos

Abstract

Endometriosis (EM) and Leiomyoma (UL) are two most frequent benign tumors of monoclonal origin affecting about 30% of all women in their reproductive age. Though known for centuries many aspects of pathogenesis and pathophysiology of EM and UL remain unknown so far. Modern molecular technologies have made tremendous impact in our understanding of both disorders. The report gives comparative analysis of molecular mechanisms of EM and UL including recent data on their origin, progression and peculiarities of manifestation. Similarities and differences of molecular mechanisms underlying their early stages are enlighten from position of systems genetics with particular emphasis on genetic specificity, gene interactions and epigenetic mechanisms regulating normal and pathologic development. Comparison of epigenetic landscapes of EM andUL progression underlying peculiarities and unique personal clinical manifestations are outlined. The origin of both tumors
as outgrowths of the relevant stem cells with mesenchymal commitment lineage migrating from endometrium/myometrium junctional zone of the uterus is hypothesized. Differences in mechanisms of stem cell origin and tumor progression resulting from epigenetic landscape peculiarities as basic reason of many clinical forms as well as unique individual manifestation of EM and UL are suggested Proofs advocating for syntropy of molecular mechanisms underlying both disorders are presented. Perspectives of the further studies of EM and UL from the platform of systems genetic with assistance of new molecular technologies and bioinformatic analysis are briefly discussed.